{"id":1415,"date":"2025-05-26T09:10:09","date_gmt":"2025-05-26T09:10:09","guid":{"rendered":"https:\/\/urolistic.com\/?p=1415"},"modified":"2025-05-26T17:12:55","modified_gmt":"2025-05-26T17:12:55","slug":"la-respuesta-inmunitaria","status":"publish","type":"post","link":"https:\/\/urolistic.com\/es\/blog\/2025\/05\/26\/la-respuesta-inmunitaria\/","title":{"rendered":"La respuesta inmunitaria"},"content":{"rendered":"\t\t
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El sistema inmunitario se localiza de manera ubicua por todo el organismo. Se compone de mol\u00e9culas solubles, extendidas por todos los l\u00edquidos org\u00e1nicos (sangre, linfa, l\u00edquido extracelular, etc.):<\/p>\n

    \n
  • las prote\u00ednas del complemento<\/li>\n
  • los anticuerpos<\/li>\n
  • los p\u00e9ptidos antimicrobianos<\/li>\n
  • las citokinas<\/li>\n
  • las aminas como la histamina<\/li>\n
  • etc<\/li>\n<\/ul>\n\n

    Otro de sus componentes son las c\u00e9lulas inmunitarias, como:<\/p>\n\n

      \n
    • neutr\u00f3filos<\/li>\n\n
    • linfocitos B y T<\/li>\n\n
    • eosin\u00f3filos y bas\u00f3filos<\/li>\n\n
    • mastocitos<\/li>\n\n
    • monocitos y macr\u00f3fagos<\/li>\n\n
    • c\u00e9lulas dendr\u00edticas<\/li>\n\n
    • c\u00e9lulas natural killer<\/li>\n\n
    • c\u00e9lulas de la microgl\u00eda<\/li>\n<\/ul>\n\n

      \u00a0\u00a0\u00a0\u00a0\u00a0Estas c\u00e9lulas, adem\u00e1s de encontrarse en algunos tejidos y \u00f3rganos linfoides como el bazo, el timo, los ganglios linf\u00e1ticos, la m\u00e9dula \u00f3sea o el tejido linfoide asociado a mucosas (MALT), tambi\u00e9n se encuentran por todos nuestros fluidos, tejidos y \u00f3rganos, donde realizan todas las funciones ya mencionadas.\u00a0<\/p>\n\n

      \u00a0\u00a0\u00a0\u00a0\u00a0No dar\u00e9 muchos detalles sobre el funcionamiento del sistema inmunitario frente a una infecci\u00f3n, pero podemos decir que la respuesta inmunitaria frente la agresi\u00f3n de un microorganismo se divide en respuesta inmunitaria innata y respuesta inmunitaria adaptativa. La primera es una respuesta mediada por la mayor\u00eda de las c\u00e9lulas inmunitarias, a excepci\u00f3n de los linfocitos, que destruyen a los microorganismos invasores por diferentes mecanismos, aunque a su paso dejan una importante reacci\u00f3n inflamatoria que causa \u201cda\u00f1os colaterales\u201d en los tejidos. La segunda, es una respuesta inmunitaria mucho m\u00e1s espec\u00edfica y que tiene memoria. Si nuestro organismo ya se ha visto atacado por un microorganismo, los linfocitos habr\u00e1n \u201ctomado nota\u201d de qu\u00e9 germen se trataba y habr\u00e1n producido anticuerpos espec\u00edficos. La primera vez les llevar\u00e1 algo de tiempo, pero, ante una nueva exposici\u00f3n, estos anticuerpos reconocer\u00e1n inmediatamente al agente agresor y desencadenar\u00e1n una respuesta mucho m\u00e1s espec\u00edfica y eficaz de entrada.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

      \n\t\t\t\t
      \n\t\t\t\t\t\t\t\t\t\n

      Bibliograf\u00eda:<\/em><\/p>\n

      Arponen S (2021).\u00a0Es la microbiota, idiota<\/em>. Alienta.<\/p>\n\n\n\n

      Godaly G, Ambite I, Svanborg C. Innate immunity and genetic determinants of urinary tract infection susceptibility. Curr Opin Infect Dis. 2015 Feb;28(1):88-96.<\/p>\n\n\n\n

      Lacerda Mariano L, Ingersoll MA. Bladder resident macrophages: Mucosal sentinels. Cell Immunol. 2018 Aug;330:136-141.\u00a0<\/p>\n\n\n\n

      Song J, Abraham SN. TLR-mediated immune responses in the urinary tract. Curr Opin Microbiol. 2008 Feb;11(1):66-73.<\/p>\n\n\n\n

      Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019 Nov 29;10:2786.<\/p>\n\n\n\n

      Steigedal M, Marstad A, Haug M, Dam\u00e5s JK, Strong RK, et al. Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection. J Immunol. 2014 Dec 15;193(12):6081-9.<\/p>\n\n\n\n

      Ueda N, Kondo M, Takezawa K, Kiuchi H, Sekii Y, et al. Bladder urothelium converts bacterial lipopolysaccharide information into neural signaling via an ATP-mediated pathway to enhance the micturition reflex for rapid defense. Sci Rep. 2020 Dec 3;10(1):21167.\u00a0<\/p>\n\n\n\n

      Hayes BW, Abraham SN. Innate Immune Responses to Bladder Infection. Microbiol Spectr. 2016 Dec;4(6):10.1128\/microbiolspec.UTI-0024-2016.\u00a0<\/p>\n\n\n\n

      O\u2019Brien VP, Hannan TJ, Schaeffer AJ, Hultgren SJ. Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection. Curr Opin Infect Dis. 2015 Feb;28(1):97-105.<\/p>\n\n\n\n

      Huang J, Fu L, Huang J, Zhao J, Zhang X, et al. Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder. Adv Sci (Weinh). 2022 Feb;9(6):e2103303.<\/p>\n\n\n\n

      Wu J, Abraham SN. The Roles of T cells in Bladder Pathologies. Trends Immunol. 2021 Mar;42(3):248-260.\u00a0<\/p>\n\n\n\n

      Billips BK, Schaeffer AJ, Klumpp DJ. Molecular basis of uropathogenic Escherichia coli evasion of the innate immune response in the bladder. Infect Immun. 2008 Sep;76(9):3891-900.<\/p>\n\n\n\n

      Nielsen KL, Stegger M, Kiil K, Godfrey PA, Feldgarden M, Lilje B, Andersen PS, Frimodt-M\u00f8ller N. Whole-genome comparison of urinary pathogenic Escherichia coli and faecal isolates of UTI patients and healthy controls. Int J Med Microbiol. 2017 Dec;307(8):497-507.\u00a0<\/p>\n\n\n\n

      Ambite I, Butler D, Wan MLY, Rosenblad T, Tran TH, Chao SM, Svanborg C. Molecular determinants of disease severity in urinary tract infection. Nat Rev Urol. 2021 Aug;18(8):468-486.<\/p>\n\n\n\n

      Ziegler T, Jacobsohn N, F\u00fcnfst\u00fcck R. Correlation between blood group phenotype and virulence properties of Escherichia coli in patients with chronic urinary tract infection. Int J Antimicrob Agents. 2004 Sep;24 Suppl 1:S70-5.<\/p>\n\n\n\n

      Sulaiman KA, Al Qahtani N, Al Muqrin M, Al Dossari M, Al Wabel A, et al. The correlation between non-O blood group type and recurrent catheter-associated urinary tract infections in critically ill patients: A retrospective study. J Int Med Res. 2022 Jul;50(7):3000605221108082.\u00a0<\/p>\n\n\n\n

      Albracht CD, Hreha TN, Hunstad DA. Sex effects in pyelonephritis. Pediatr Nephrol. 2021 Mar;36(3):507-515.\u00a0<\/p>\n\n\n\n

      Wnorowska U, Piktel E, Deptu\u0142a P, Wollny T, Kr\u00f3l G, et al. Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection. Sci Rep. 2022 Nov 10;12(1):19164.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

      El sistema inmunitario se localiza de manera ubicua por todo el organismo. Se compone de mol\u00e9culas solubles, extendidas por todos los l\u00edquidos org\u00e1nicos (sangre, linfa, l\u00edquido [\u2026]<\/span><\/p>\n","protected":false},"author":1,"featured_media":1544,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-1415","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud-urologica"],"yoast_head":"\nLa respuesta inmunitaria | Urolistic<\/title>\n<meta name=\"description\" content=\"Redescubre el bienestar con Urolistic, el proyecto de la Dra. 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